Zenas BioPharma Launches as a Cross-Border Biopharmaceutical Company to Bring Innovation to the Development and Delivery of Immune-Based Therapies

Lead product candidate, ZB001, has first-in-class potential in China for Thyroid Eye Disease

Rapidly advancing seven pipeline programs, including three worldwide, with best-in-class potential in autoimmune and rare diseases

Expanding a proven leadership team of veteran life science industry executives

Company founded and initially funded by Tellus BioVentures and Fairmount

HONG KONG and BOSTON, March 23, 2021 (GLOBE NEWSWIRE) — Zenas BioPharma (“Zenas”) launched today as a cross-border biopharmaceutical company committed to becoming a global leader in the development and delivery of immune-based therapies for patients in China and throughout the world.

Zenas was founded and initially funded by Tellus BioVentures, LLC (“Tellus”) and Fairmount Funds Management LLC (“Fairmount”) and is additionally backed by a syndicate of leading global life science investment funds including Quan Capital, WuXi Biologics Healthcare Ventures and Wellington Management.

Lonnie Moulder, Managing Member of Tellus and Founder of Zenas, serves as Executive Chairman and Interim Chief Executive Officer. As a veteran life sciences founder and executive, he brings to Zenas a track record of success and the necessary skills to navigate the global biopharmaceutical landscape. Mr. Moulder has assembled an experienced leadership team with strong credentials in acquiring, developing and commercializing products across the globe.

“We are excited about the launch of Zenas BioPharma and its pipeline of differentiated product candidates. These potentially best-in-class products are intended to bring innovation to patients with underserved diagnoses while also maximizing value across the healthcare ecosystem,” said Mr. Moulder. “The expanding Zenas leadership team and our network of business partners will drive operational excellence to deliver potentially transformative therapies to improve the lives of people living with autoimmune and rare diseases.”

“We are thrilled to invest in and support this new venture lead by a proven and experienced team,” added Marietta Wu, MD, Ph.D., MBA, Managing Director at Quan Capital and Zenas Board Member. “Immunology is an area of transformative innovation poised to solve great unmet medical needs. We are confident that by leveraging cross border research and development capabilities and resources, Zenas will rapidly advance its current portfolio and establish its global leadership with an expanded pipeline coupled with a strong footprint in China.”

Rapidly Advancing Pipeline

Zenas debuts with a deep pipeline of seven innovative immune-based therapeutics that will continue to expand through a successful business development strategy. Zenas owns worldwide rights to three of the seven pipeline programs, which uniquely positions the Company to be global in scope.

Zenas innovation is defined by the selection of product candidates that are designed with best-in-class potential and then advanced utilizing differentiated development and commercial strategies to address patient needs AND the value requirements of the dynamic healthcare environment. Zenas innovation further includes acquiring or discovering first-in-class product candidates based upon new knowledge in the evolving field of immunology.

ZB001 and ZB011

Zenas is developing its lead product candidate ZB001, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (mAb), for the potential treatment of patients in China with thyroid eye disease (TED). TED is a debilitating condition that significantly impacts quality of life and can cause proptosis (“bulging eyes”), double vision and vision loss. ZB001, a potential first-in-class product in China, was exclusively in-licensed from Viridian Therapeutics, Inc. (“Viridian”) (NASDAQ: VRDN).

More than 100 oncology patients have previously been treated with the antibody in US and EU studies, under the name AVE-1642, enabling understanding of its pharmacokinetic and pharmacodynamic profile, as well as its safety and tolerability. Viridian maintains all rights outside of China and is developing the IGF1R mAb under the name VRDN-001. This program is advancing rapidly with an expected Investigational New Drug (“IND”) application filing by Viridian in late 2021, followed by a Zenas filing in China. Data from the first clinical trial involving patients is expected to be available in 2022.

In parallel with ZB001 development, Viridian and Zenas initiated the ZB011 program, which seeks to improve IGF1R-targeted antibodies to further enhance dosing and convenience.

ZB002, ZB003 and ZB004

The Zenas pipeline also includes three potentially best-in-class mAbs (ZB002, ZB003, ZB004) exclusively in-licensed worldwide from Xencor, Inc. (NASDAQ: XNCR). These three mAbs were engineered with XmAb™ technology for improved potency, half-life, and stability and are undergoing IND-enabling studies to support clinical development for both new and established autoimmune disease indications.

ZB005 and ZB006

Zenas additionally entered a collaboration with Dianthus Therapeutics, Inc. (“Dianthus”) that provides China rights for two mAb programs, ZB005 and ZB006. Dianthus is a privately held biotechnology company focused on the discovery and development of monoclonal antibody therapeutics that modulate the immune complement system for the treatment of autoimmune diseases. IND-enabling activities are underway for ZB005, the first of the two programs.

About Zenas BioPharma

Zenas BioPharma is a cross-border (China-USA based) biopharmaceutical company committed to becoming a global leader in the development and delivery of immune-based therapies for patients in China and around the world. Zenas is rapidly advancing a deep pipeline of innovative therapeutics that continues to grow through our successful business development strategy. Our experienced leadership team and network of business partners drive operational excellence to deliver potentially transformative therapies to improve the lives of those facing autoimmune and rare diseases. For more information about Zenas BioPharma, please visit and follow us on Twitter at @ZenasBioPharma and LinkedIn.


Investor Contact:

Zenas BioPharma
[email protected]

Media Contact:

Lauren Bartlett
Zenas BioPharma
[email protected]

Latest News

Conagen’s Novel Solution to Making Natural Capsaicin by Fermentation Accessible

Bedford, Mass., April 22, 2021 (GLOBE NEWSWIRE) — Scalable, sustainable capsaicin ingredients for its use in food, consumer and industrial products have now become more accessible. Conagen announced it has successfully scaled-up its fermentation process for the production of premium capsaicin and its related capsaicinoid molecules. Chili peppers are widely used as a food additive in spicy […]

Global Pandemic Fueled Renewed Investor Interest in Silver in 2020

Record Silver-Backed Exchange-Traded Product Inflows Drove Global Holdings to Over One Billion Ounces; Coin and Bar Demand Rose to a Four-Year High WASHINGTON, April 22, 2021 (GLOBE NEWSWIRE) — Considerable growth in silver investment was the chief driver of the metal’s 27 percent average price gain in 2020. Leading the way was substantial demand for […]

โรงงานใหม่ของ Nikkiso Cryo Inc. เพิ่มการผลิตปั๊มไครโอเจนิค

ลาสเวกัส, April 22, 2021 (GLOBE NEWSWIRE) — Nikkiso Cryo Inc. (NCI) ในเมืองลาสเวกัส รัฐเนวาดา ซึ่งเป็นสมาชิกของ Nikkiso Clean Energy and Industrial Gases Group (กลุ่ม) และเป็นส่วนหนึ่งของ Nikkiso Co., Ltd (ญี่ปุ่น) ได้ประกาศเกี่ยวกับโรงงานใหม่ซึ่งจะเพิ่มประสิทธิภาพและขีดความสามารถในการผลิตปั๊มไครโอเจนิค โรงงานใหม่ที่ใหญ่ขึ้นของ NCI เป็นสิ่งจำเป็นเนื่องจากการเติบโตและความต้องการผลิตภัณฑ์และบริการปั๊มไครโอจีนิคอย่างต่อเนื่องของตลาด LNG ทั่วโลก (หลักๆ คือสถานีส่งออกและนำเข้า LNG) โรงงานสำนักงานขนาด 15,000 ตารางฟุตอยู่ใกล้กับสถานที่ทดสอบการผลิตหลัก ซึ่งมีการปรับปรุงประสิทธิภาพในการดำเนินงาน ความปลอดภัย และขีดความสามารถในการผลิตที่เพิ่มขึ้นอย่างมาก ในจำนวนนี้ยังมีระบบหอเผาทิ้งระดับพื้นดินใหม่ที่มีประสิทธิภาพและขีดความสามารถในการผลิตที่ดีขึ้น อีกทั้งยังมีการติดตั้งเครนโอเวอร์เฮดไฟฟ้าประเภทที่ 1 แบบที่ 1 บนแผงทดสอบ ซึ่งช่วยลดต้นทุนและเพิ่มผลผลิตโดยช่วยให้สามารถทำงานหลายอย่างในเวลาเดียวกัน เพิ่มความปลอดภัยโดยอนุญาตให้สามารถยกและติดตั้งปั๊มหลายตัวสำหรับการทดสอบ รวมถึงได้รับการรับรองสำหรับพื้นที่อันตราย “นี่เป็นก้าวต่อไปที่น่าตื่นเต้นสำหรับบริษัทของเราและเป็นประโยชน์อย่างมากสำหรับลูกค้าของเรา NCI จะสามารถเพิ่มผลผลิตและลดเวลาในการผลิตได้” Daryl […]

AB InBev 100+ Accelerator partners with The Coca-Cola Company, Colgate-Palmolive and Unilever for Sustainable Startup Innovation

NEW YORK, April 22, 2021 (GLOBE NEWSWIRE) — Today, The Coca-Cola Company, Colgate-Palmolive Company and Unilever have joined the Anheuser-Busch InBev (AB InBev) 100+ Accelerator to fund and pilot sustainable innovation in supply chains. Launched in 2018, the 100+ Accelerator is a global incubator program that works to solve supply chain challenges across water stewardship, […]