{"id":53684,"date":"2022-01-07T07:01:54","date_gmt":"2022-01-07T07:01:54","guid":{"rendered":"https:\/\/pr.asianetpakistan.com\/?p=84926"},"modified":"2022-01-07T07:01:54","modified_gmt":"2022-01-07T07:01:54","slug":"philogen-announces-publication-of-pet-clinical-data-with-proprietary-ultra-high-affinity-fap-targeting-small-molecule-ligand-oncofap","status":"publish","type":"post","link":"https:\/\/malaysiantribune.com\/philogen-announces-publication-of-pet-clinical-data-with-proprietary-ultra-high-affinity-fap-targeting-small-molecule-ligand-oncofap\/","title":{"rendered":"Philogen announces publication of PET clinical data with proprietary ultra-high affinity FAP-targeting small molecule ligand (OncoFAP)"},"content":{"rendered":"
\n

Philogen<\/strong> announces <\/strong>publication of <\/strong>PET clinical<\/strong> data <\/strong>with proprietary ultra-high affinity<\/strong> FAP-targeting small molecule ligand<\/strong> (OncoFAP)<\/strong><\/p>\n

Translational <\/em>studies performed at <\/em>the European Institute for Molecular Imaging <\/em>and the Department of Nuclear Medicine <\/em>(University<\/em> and University Hospital<\/em> of M\u00fcnster)<\/em> show <\/em>rapid <\/em>and selective<\/em> tumor uptake of OncoFAP with unprecedented selectivity against healthy organs<\/em> in cancer patients<\/em><\/p>\n

Philogen<\/em>, in collaboration with Senn Chemicals,<\/em> has already produced <\/em>the equivalent of <\/em>1 million GMP doses<\/em> of <\/em>clinical-grade <\/em>OncoFAP-DOTAGA<\/em><\/p>\n

Siena<\/strong>, Italy, <\/strong>January<\/strong> 7<\/strong>th<\/strong><\/sup>, 202<\/strong>2<\/strong> – Philogen S.p.A., a clinical-stage biotechnology company focused on antibody and small molecule-based targeted therapeutics, announces that its wholly-owned Swiss subsidiary, Philochem AG, has co-authored a new translational study on 68<\/sup>Ga-OncoFAP, a best-in-class FAP-targeting small molecule for applications in cancer and inflammation.<\/p>\n

The paper, entitled \u201cTranslational imaging of the fibroblast activation protein (FAP) using the new ligand \u201c[68Ga]Ga-OncoFAP-DOTAGA\u201d, was published in the peer-reviewed journal European Journal of Nuclear Medicine and Molecular Imaging and reports the novel pre-clinical and clinical findings obtained with 68<\/sup>Ga-OncoFAP.<\/p>\n

The data confirmed the rapid and selective accumulation of 68<\/sup>Ga-OncoFAP in solid tumor lesions in disease models and in patient cases. Additionally, 68<\/sup>Ga-OncoFAP showed excellent selectivity against healthy organs, including kidneys, at early time points (i.e., already one hour after systemic administration) and an impressive tumor-targeting performance in mice and in patients with different stages of disease (i.e., from localized to disseminated disease).<\/p>\n

Dario Neri, Chief Executive Officer of <\/strong>Philogen<\/strong> commented:<\/strong> \u201cWe are delighted with the translational results presented in our recent paper which showed OncoFAP\u2019s strong selectivity against healthy organs in cancer patients. In order to pave the way towards a broader adoption of this technology, we have established a network of Nuclear Medicine centers across various continents to support our future clinical studies. The equivalent of 1,000,000 GMP-grade doses of OncoFAP-DOTAGA has already been produced in collaboration with Senn Chemicals.\u201d<\/p>\n

The results presented in this article stem from a collaboration between the European Institute for Molecular Imaging<\/em> and the Department of Nuclear Medicine <\/em>at the University and University Hospital of Mu\u0308nster and the scientists at Philochem AG.<\/p>\n

OncoFAP has been manufactured in GMP conditions at Senn Chemicals AG, a CDMO in peptide synthesis and small molecules with expertise in small scale GMP production.<\/p>\n

Fibroblast Activation Protein (FAP) has recently emerged as a tumor-associated antigen with abundant and selective expression in the majority of human solid malignancies. The discovery of OncoFAP, together with its preclinical characterization, has been recently reported in Proc Natl <\/em>Acad<\/em> Sci USA<\/em> in April 2021.<\/p>\n

Philochem\u2019s OncoFAP-derivates are the small organic ligands with the highest affinity to the FAP antigen reported to date.<\/p>\n

OncoFAP is currently being studied as modular component for the generation of therapeutic products enabling the targeted delivery of a potent beta-emitter (lutetium-177), of fluorescein-specific CAR T-cells, and of highly cytotoxic auristatin derivatives.<\/p>\n

The article can be accessed from the European Journal of Nuclear Medicine and Molecular Imaging<\/strong> website under the following l<\/a>i<\/a>nk<\/a>.<\/p>\n

About Philogen<\/strong><\/p>\n

Philogen is a Swiss-Italian clinical-stage biotechnology company listed on the Italian Stock Exchange. It is engaged in the discovery and development of novel pharmaceutical and biopharmaceutical products. Philogen\u2019s strategy is to deliver bioactive agents, for example cytokines or drugs, to the site of disease using antibodies and other ligands that specifically and efficiently target stromal antigens. This technology has generated a strong proprietary pipeline of clinical-stage products and preclinical compounds in an array of disease indications. Philogen is headquartered in Siena, Italy, and has research activities at its subsidiary company Philochem near Zurich, Switzerland. Philogen has signed agreements with several major pharmaceutical companies. For more information, please visit www.philogen.com<\/a> and www.philochem.com<\/a>.<\/p>\n

Philogen contacts <\/strong><\/p>\n

Dr. Christian Lizak (Business Development), christian.lizak@philogen.com<\/a><\/p>\n

Dr. Emanuele Puca (Investor Relations), emanuele.puca@philogen.com<\/a><\/p>\n

+41 (0) 43 544 88 00<\/p>\n

Consilium Strategic Communications contacts <\/strong><\/p>\n

Mary-Jane Elliott, Davide Salvi<\/p>\n

Philogen@consilium-comms.com<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Philogen announces publication of PET clinical data with proprietary ultra-high affinity FAP-targeting small molecule ligand (OncoFAP) Translational studies performed at the European Institute for Molecular Imaging and the Department of Nuclear Medicine (University and University Hospital of M\u00fcnster) show rapid and selective tumor uptake of OncoFAP with unprecedented selectivity against healthy organs in cancer patients [\u2026]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"yoast_head":"\nPhilogen announces publication of PET clinical data with proprietary ultra-high affinity FAP-targeting small molecule ligand (OncoFAP) - Malaysian Tribune<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/malaysiantribune.com\/philogen-announces-publication-of-pet-clinical-data-with-proprietary-ultra-high-affinity-fap-targeting-small-molecule-ligand-oncofap\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Philogen announces publication of PET clinical data with proprietary ultra-high affinity FAP-targeting small molecule ligand (OncoFAP) - 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