{"id":57950,"date":"2022-05-19T11:41:59","date_gmt":"2022-05-19T11:41:59","guid":{"rendered":"https:\/\/malaysiantribune.com\/?p=57950"},"modified":"2022-05-19T11:41:59","modified_gmt":"2022-05-19T11:41:59","slug":"centrient-pharmaceuticals-announces-its-achievement-of-a-significant-milestone-in-the-clean-production-of-antibiotics","status":"publish","type":"post","link":"https:\/\/malaysiantribune.com\/centrient-pharmaceuticals-announces-its-achievement-of-a-significant-milestone-in-the-clean-production-of-antibiotics\/","title":{"rendered":"Centrient Pharmaceuticals announces its achievement of a significant milestone in the clean production of antibiotics"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Being the first company to publicly announce 100% PNEC compliance for its entire oral antibiotics product range<\/h4>\n\n\n\n<p>Rijswijk, The Netherlands, May 19, 2022 (GLOBE NEWSWIRE) &#8212;<\/p>\n\n\n\n<p>Summary<\/p>\n\n\n\n<ul><li><em>Centrient Pharmaceuticals reached a significant milestone in the clean production of its antibiotics, with the lowest environmental impact and minimizing the potential contribution to antimicrobial resistance<\/em><\/li><li><em>The company is the first to publicly announce that Its entire supply chain of oral antibiotics \u2013 including its own and supplier manufacturing sites &#8211; is fully compliant with the stringent <\/em><em>Predicted No Effect Concentration (PNEC) discharge targets set by the AMR Industry Alliance<\/em><\/li><li><em>This achievement demonstrates Centrient Pharmaceuticals\u2019 commitment and leadership in the responsible production of antibiotics.<\/em><\/li><\/ul>\n\n\n\n<p><strong>Centrient Pharmaceuticals announces 100% compliance with the<\/strong><strong> stringent Predicted No Effect Concentration (PNEC) discharge targets set by the AMR Industry Alliance for clean manufacturing of its full oral antibiotics product range. This standard covers both Centrient\u2019s sites and its suppliers\u2019 sites. This achievement positions the company as a frontrunner in the industry with the delivery of responsibly-produced antibiotics, which minimize the possible contribution to antimicrobial resistance.<\/strong><\/p>\n\n\n\n<p>The PNEC discharge target is the concentration of an antibiotic in water at which there is unlikely to be a risk of adverse environmental effects or of antimicrobial resistance (AMR) developing. These scientific, risk-based targets were developed by the AMR Industry Alliance and cover around 120 active pharmaceutical ingredients (APIs) used in antibiotic manufacturing. Each individual antibiotic has a corresponding PNEC value, published in the AMR Industry Alliance table of Recommended PNECs for Risk Assessments (updated periodically).<\/p>\n\n\n\n<p>High concentrations of antibiotic residues in factory wastewater can create hotspots of resistant bacteria which may lead to AMR. While manufacturing is just one of the contributors to the emergence of AMR in the environment, its impact cannot be overlooked. AMR is a major threat to global public health as well as to the healthcare industry. Many standard medical procedures such as organ transplants, chemotherapy, and surgeries such as caesarean sections become much more dangerous without effective antibiotics to prevent and treat infections. Antibiotics are the cornerstone of our modern healthcare system, and complying with PNEC standards enables manufacturers to ensure supply of these critically important medicines does not contribute to the risk of AMR.<\/p>\n\n\n\n<p>The PNEC values are increasingly being recognized as the standard for antibiotic discharge concentrations in water and are expanding beyond Alliance companies and their supply chains. For example, tenders in the UK and Germany (health insurer AOK) include a specific reference to the PNEC discharge targets. Also, companies assessed externally by organizations such as the Access to Medicine Foundation will have public exposure for their performance on PNECs.<\/p>\n\n\n\n<p>As a strong advocate for sustainable manufacturing, Centrient Pharmaceuticals became a founding board member of the AMR Industry Alliance in 2017, working with partners to raise awareness and deliver solutions to the AMR issue. Since then, the company\u2019s own journey to reaching full compliance has included establishing state-of-the-art wastewater treatment facilities at all their sites worldwide and developing tests for measuring antibiotic activity in wastewater streams, leading to a fully clean and PNEC-compliant supply chain.<\/p>\n\n\n\n<p>\u201c<em>We are proud to be the first in our industry to publicly announce PNEC compliance for our oral antibiotics product supply chain.<\/em><\/p>\n\n\n\n<p><em>At Centrient Pharmaceuticals, our commitment to Sustainability is in our DNA \u2013 we ensure that the way in which we produce pharmaceuticals has the lowest environmental impact and does not contribute to AMR. We are proud of our PureActives\u00ae enzymatic low-carbon technology, ISO 14001 certification of all our sites, and Board positions at the Pharmaceutical Supply Chain Initiative and AMR Industry Alliance.<\/em><\/p>\n\n\n\n<p><em>We will continue to work with customers, suppliers, industry and government decision-makers across the value chain to make the supply and buying of antibiotics sustainable to curb AMR.<\/em><em>\u201d,<\/em> says Rex Clements, CEO at Centrient Pharmaceuticals.<\/p>\n\n\n\n<p>Read our whitepaper \u2018Manufacturing sustainable antibiotics for the future\u2019 <a href=\"https:\/\/www.google.com\/url?q=https:\/\/www.globenewswire.com\/Tracker?data%3DPvR_oOpZxnIWtcbVgo9oxbf-XNZAmXP2CWFck5yb5zZGEEMNKii0H68Gf5dv42G3R9_SlKTymnQpDpriRXNzyGHQsattKPQh4uN2Sw_HfnaWjkzTzCumA2KQvL4PbCUJ7X4_zX61Ki8RwFeNHuudhVRVprdEJGik3D0VtAJoNf8%3D&amp;source=gmail-html&amp;ust=1653033835074000&amp;usg=AOvVaw1XAcdSBMJexVq4yrzG_q8u\" target=\"_blank\" rel=\"noreferrer noopener\">here<\/a>.<\/p>\n\n\n\n<p><strong>About Centrient Pharmaceuticals<\/strong><\/p>\n\n\n\n<p>Centrient Pharmaceuticals is the global leader in the production and commercialisation of sustainable antibiotics, next-generation statins, and anti-fungals. We produce and sell intermediates, active pharmaceutical ingredients and finished dosage forms.<\/p>\n\n\n\n<p>We stand proudly at the centre of modern healthcare, as a maker of essential and life-saving medicines. With our commitment to Quality, Reliability and Sustainability at the heart of everything we do, our over 2,200 employees work continuously to meet our customers\u2019 needs. We work towards a sustainable future by actively participating in the fight against antimicrobial resistance.<\/p>\n\n\n\n<p>Founded 150 years ago as the \u2018Nederlandsche Gist- en Spiritusfabriek\u2019, our company was known as Gist Brocades and more recently DSM Sinochem Pharmaceuticals. Headquartered in Rijswijk (Netherlands), we have production facilities and sales offices in China, India, the Netherlands, Spain, the United States and Mexico. Centrient Pharmaceuticals is wholly owned by Bain Capital Private Equity, a leading global private investment firm.<\/p>\n\n\n\n<p>For more information please visit <a href=\"https:\/\/www.google.com\/url?q=http:\/\/www.centrient.com&amp;source=gmail-html&amp;ust=1653033835074000&amp;usg=AOvVaw0wsNYz6vIhe20o1L_4dAFm\" target=\"_blank\" rel=\"noreferrer noopener\">www.centrient.com<\/a> or contact Centrient Pharmaceuticals Corporate Communications, Alice Beijersbergen, Director Branding &amp; Communications. E-Mail: <a href=\"https:\/\/www.google.com\/url?q=https:\/\/www.globenewswire.com\/Tracker?data%3DA-4XQIziFJgDH86DBA2Ap8VDNNELR3Padk6NWFzEffSRo8WivzSdnAugCHQ_fbzen0Co8ERc_FU8yuZFFqWSJrpaRFu5sgHrZ638t_ZDCtJj4AJyhX6VyOi01fNbFJ-y&amp;source=gmail-html&amp;ust=1653033835074000&amp;usg=AOvVaw1lNh8yM0vZ6F5SYsOCovvk\" target=\"_blank\" rel=\"noreferrer noopener\">alice.beijersbergen@centrient.com<\/a>.<br><strong>About the AMR Industry Alliance<\/strong><\/p>\n\n\n\n<p>The&nbsp;AMR Industry Alliance&nbsp;was&nbsp;formed in 2017. With approximately&nbsp;100 life sciences companies and trade associations,&nbsp;it&nbsp;represents nearly one-third of the volume of sales and the majority of all novel products. Members&nbsp;have committed to report on activities they are undertaking&nbsp;in the areas of research &amp; science, access to antibiotics and appropriate use&nbsp;of these, as well as responsible environmental manufacturing&nbsp;to tackle the rapid spread of&nbsp;antimicrobial resistance.&nbsp;If AMR remains unchecked, the annual death toll could climb from 700,000 each year to 10 million by 2050 and the economic impacts could be on par with&nbsp;those of&nbsp;the 2008 financial crisis.&nbsp;The AMR Industry Alliance ensures that signatories collectively deliver on the specific commitments made in the&nbsp;Industry Declaration on AMR&nbsp;and the&nbsp;Roadmap&nbsp;for Progress on Combating AMR&nbsp;and measures progress made in the fight against AMR.<br>Forward-looking statements<\/p>\n\n\n\n<p>This press release may contain forward-looking statements with respect to Centrient Pharmaceuticals\u2019 future financial performance and position. Such statements are based on current expectations, estimates and projections of Centrient and information currently available to the company. Centrient cautions readers that such statements involve certain risks and uncertainties that are difficult to predict and therefore it should be understood that many factors can cause actual performance and position to differ materially from these statements. Centrient has no obligation to update the statements contained in this press release, unless required by law. The English language version of the press release is governing.<\/p>\n\n\n\n<pre class=\"wp-block-preformatted\">Alice Beijersbergen\nCentrient Pharmaceuticals\n+31 (6) 823 579 56\n<a href=\"mailto:alice.beijersbergen@centrient.com\" target=\"_blank\" rel=\"noreferrer noopener\">alice.beijersbergen@centrient.com<\/a><\/pre>\n","protected":false},"excerpt":{"rendered":"<p>Being the first company to publicly announce 100% PNEC compliance for its entire oral antibiotics product range Rijswijk, The Netherlands, May 19, 2022 (GLOBE NEWSWIRE) &#8212; Summary Centrient Pharmaceuticals reached a significant&#8230;<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Centrient Pharmaceuticals announces its achievement of a significant milestone in the clean production of antibiotics - 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